Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Inflammation and stem cells in gastrointestinal carcinogenesis.

Chronic inflammation-induced carcinogenesis is a commonly accepted entity and is frequently seen within the gastrointestinal tract, although the underlying mechanisms remain unclear. Alterations in specific oncogenes and tumor suppressor genes are known to be responsible for malignant transformation. Nevertheless, the inflammatory microenvironment classically affects tumor promotion in its role...

Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis

Inflammation can be induced by chronic infection, inflammatory diseases and physicochemical factors. Chronic inflammation is estimated to contribute to approximately 25% of human cancers. Under inflammatory conditions, inflammatory and epithelial cells release reactive oxygen (ROS) and nitrogen species (RNS), which are capable of causing DNA damage, including the formation of 8-oxo-7,8-dihydro-...

Crosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability

The barrier function of the intestine is essential for maintaining the normal homeostasis of the gut and mucosal immune system. Abnormalities in intestinal barrier function expressed by increased intestinal permeability have long been observed in various gastrointestinal disorders such as Crohn's disease (CD), ulcerative colitis (UC), celiac disease, and irritable bowel syndrome (IBS). Imbalanc...

Michael Quante and Timothy Cragin Wang Carcinogenesis Inflammation and Stem Cells in Gastrointestinal

Inflammation and Carcinogenesis

We consider that inflammatory substances play an important role in the carcinogenesis process. In the process, cytokines and growth factor secreted by cells can actively recruit immune cells in the carcinogenesis microenvironment, further, promote carcinogenesis progression. The carcinogenesis microenvironment even subverted the immune system, moreover, enhanced the carcinogenesis through immun...